Columbia University licenses next-generation DNA
sequencing technology
Columbia University announces that it recently
executed an exclusive license agreement for a next generation DNA
sequencing technology to Intelligent Bio-Systems (IBS), Inc. This
innovative DNA-sequencing technology was invented by Dr. Jingyue Ju,
professor of Chemical Engineering and head of DNA Sequencing and
Chemical Biology at the Judith P. Sulzberger, M.D. Columbia Genome
Center at Columbia University. The fundamentals of this new technology
are being published on-line today by in the Proceedings of the
National Academy of Sciences (PNAS). This research paper describes the
details of the Sequencing by Synthesis Chemistry and how the approach
overcomes accuracy limitations of other next generation DNA sequencing
systems.
It was also recently announced that Columbia
University in collaboration with the Waltham, Mass. based Intelligent
Bio-Systems, is one of only two recipients of the Near-Term Technology
Development for Genome Sequencing grants from the National Human
Genome Research Institute (NHGRI) of the National Institutes of Health
(NIH) (www.genome.gov/19518500). This grant of $425,000 is for the
development of a "High-Throughput DNA Sequencing by Synthesis Platform."
"The collaboration between Dr. Ju at Columbia and
Intelligent Bio-Systems is an important development to bring this
powerful technology to both researchers and clinicians in the near
future," said Dr. Steven Gordon, Chief Executive Officer at IBS. "Completing
the license was a key step in uniting Dr. Ju's seminal sequencing
chemistry and IBS's molecular biology and engineering expertise. We
are poised to offer a simple, cost effective platform that will enable
many researchers and clinicians to use this next-generation DNA
sequencing technology in their own laboratories."
Dr. Ju is a prolific inventor of new technologies
for applications in genomics using chemistry and molecular engineering
approaches. He is credited with being one of the primary inventors of
the fluorescent energy transfer chemistry for 4-color Sanger
sequencing being used by virtually all of the current generations of
DNA sequencers that were used to complete the Human Genome Project.
Source / Further
information:
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Publishing date: 12-Dec-2006
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From its conception in 1995, the Judith P.
Sulzberger, M.D.,
Columbia Genome Center (CGC) has served as a bridge between
the biomedical and science/engineering communities of the two
Columbia University campuses, the main campus in Morningside
Heights and the Medical Center campus in Washington Heights. The
CGC was born as an interdisciplinary consortium of scientists and
engineers dedicated to the generation of technology, information
science, systems biology, and population genetic theory required
to transform information from the genome to the study of biology
and the practice of medicine. Today, more than 70 scientists
collaborate on initiatives to further illuminate the genome.
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Founded in 1754 as King's College,
Columbia
University in the City of New York is the fifth oldest
institution of higher learning in the United States and is one of
the world's leading academic and research institutions, conducting
pathbreaking research in medicine, science, engineering, the arts,
and the humanities.
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Intelligent Bio-Systems, Inc. is a privately
held company located in Waltham, Mass. Since founding in 2005 it
has focused on the development of next-generation DNA sequencing,
gene expression and diagnostic systems based on proprietary
instruments, chemistry, and consumables. The company has committed
to deliver working instruments to the laboratories of a few early
access collaborators during the coming year.
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